Endothelial dysfunction is a well-known long term effect of metabolic derangements in adults. I am interested in how maternal metabolic derangements during pregnancy affect feto-placental endothelial function, such as angiogenesis, barrier function and proliferation.
MicroRNAs are increasingly recognized as key players in endothelial cell regulation. Thus, the role of these so called AngiomiRs in altered feto-placental endothelial function in GDM is a further focus of my research. The findings will help to understand how maternal metabolism affects feto-placental endothelial function and consequently, may affect fetal development.
Strutz et al., submitted to Cardiovasc Res 2017
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Loegl et al., Reproduction 2016
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Diaz-Perez et al., Cell Adh Migr. 2016